Search results for "TP53 expression"

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DNA ploidy and S-phase fraction, but not p53 or NM23-H1 expression, predict outcome in colorectal cancer patients. Result of a 5-year prospective stu…

2002

Purpose: The aim of this study was to determine TP53 and NM23-H1 immunoreactivity, DNA ploidy, and S-phase fraction (SPF) in a series of 160 patients undergoing resective surgery for primary operable colorectal cancer (CRC) and to establish whether these alterations have any clinical value in predicting CRC patients' prognosis. Methods: TP53 and NM23-H1 expressions were evaluated on paraffin-embedded tissue by immunohistochemistry and DNA-ploidy and SPF on frozen tissue by flow-cytometric analysis. Results: The median follow-up time in our study group was 71 months (range 34-115 months). P53 protein expression was associated with distal tumors (P < 0.05) and DNA aneuploid tumors (P < …

OncologyCancer Researchmedicine.medical_specialtyPathologyFlow-cytometric variableTime FactorsTumor suppressor geneColorectal cancerPrognosiSettore MED/06 - Oncologia MedicaColonRectumBiologyAdenocarcinomaDisease-Free SurvivalS PhasePredictive Value of TestsInternal medicinemedicineBiomarkers TumorHumansStage (cooking)Prospective cohort studyMonomeric GTP-Binding ProteinsNeoplasm StagingTP53 expressionHematologyPloidiesGeneral MedicineDNA NeoplasmCell cycleNM23 Nucleoside Diphosphate Kinasesmedicine.diseaseColorectal cancerAdenocarcinoma MucinousImmunohistochemistrySurvival Analysismedicine.anatomical_structureTreatment OutcomeOncologyNucleoside-Diphosphate KinaseImmunohistochemistryLymph NodesTumor Suppressor Protein p53Colorectal NeoplasmsCell DivisionTranscription FactorsJournal of cancer research and clinical oncology
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